Kevin J. Downes, MD

Kevin Downes, MD is an Attending Physician in the Division of Infectious Diseases, a faculty member of the Pediatric Infectious Diseases Epidemiology and Antimicrobial Stewardship (IDEAS) research group of the Center for Pediatric Clinical Effectiveness (CPCE), and a faculty member of the Center for Clinical Pharmacology at Children’s Hospital of Philadelphia (CHOP). He is also an Assistant Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Downes’ research focuses on antibiotic use in critically ill and immunocompromised children. Specifically, his research interests include antimicrobial pharmacokinetics/pharmacodynamics (PK/PD), antibiotic-associated acute kidney injury, and the roles of biomarkers in the management of children with infectious diseases. Dr. Downes has particular interests in individualized dose optimization of antimicrobials and the ability of patient-centric sampling to improve therapeutic drug monitoring in children. His team also conducts research focused on the prevention and management of infections in pediatric solid organ transplant recipients.

“Patient-centric microsampling can facilitate informative sample collection and promote personalized antibiotic dosing through therapeutic drug monitoring.”