Advancing the collection and analysis of PFAS in blood

Recently, the National academies of Sciences, Engineering and Medicine (NASEM) has recommended that people test their water and blood for per- and polyfluorinated substances (PFAS). This is a change from the past direction. The blood test places people into one of three categories based on the sum of seven pertinent PFAS. This sum then informs clinical care depending on the PFAS levels.

​Traditionally, PFAS tests have been conducted with serum. This is true of the CDC studies and most academic cohorts. Only recently has technology developed to a point where both a volumetric sampling device and highly sensitive instrumentation can come together to assist the analytical challenge of a remote PFAS blood test. Equally important are the suite of isotopically labeled standards that are spiked into every sample to aid in quantitation. This approach is known as isotope dilution and it is considered the gold-standard of quantitation.

This talk aims to educate the viewer on this new approach for PFAS testing, and will be of particular interest to:

  • Health and safety officers
  • First responders
  • Academic researchers
  • Curious citizens​​​​​​​

​What you will learn

The vast majority of people have PFAS in their blood. It is a matter of what analytes and how much.

  • Attendees will learn about isotope dilution quantitation.
  • Attendees will learn about linear and branched PFAS isomers.
  • The basics of LC-MS/MS will be presented.
  • The talk will also include discussions on half-lives and bioaccumulation.

Speakers

Andrew Patterson

VP of Innovation and Development, Specialty Services, Eurofins Environment North America

Andrew is the VP of Innovation and Development for Eurofins Environment Testing America for the Specialty Services division. He brings over 20 years of experience in the environmental laboratory industry with a focus on GC-HRMS and LC-MS/MS analyses. These approaches have focused on PCBs, dioxins, brominated flame-retardants, PFAS, emerging contaminants and human biomonitoring. He is among a handful of Eurofins scientists focused on techniques such as Non-target Analysis (NTA) via LC-QToF instrumentation. Recently, Andrew led the development for the PFAS Exposure fingerprick blood test. Andrew holds a Bachelor’s of Science in Microbiology with a concentration in Biochemistry from Cal Poly San Luis Obispo, CA, USA.

Neil Spooner

Director Spooner Bioanalytical Solutions & Chair Patient Centric Sampling Interest Group

Neil is the Founder of Spooner Bioanalytical Solutions, helping companies to integrate biological fluid microsampling, and patient centric sampling and analysis into workflows. He also works with organizations to develop technologies and introduce them to the market. Neil also assists organizations with their understanding of emerging trends in the pharmaceutical industry and bioanalysis. Neil is a Senior Visiting Research Fellow at the University of Hertfordshire, Editor in Chief of the journal, Bioanalysis, Founder of the Patient Centric Sampling Interest Group and Co-Chair of the Reid Bioanalytical Forum. He has published over 70 peer reviewed manuscripts and delivered over 50 podium presentations.​​​​​​​

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